Stellate Ganglion Block (SGB) – The Science







  1. Alshak, Mark N. and Joe M Das. “Neuroanatomy, Sympathetic Nervous System.” StatPearls, StatPearls Publishing, 26 July 2021.
  2. Goldstein, B. “Anatomy of the peripheral nervous system.” Physical medicine and rehabilitation clinics of North America vol. 12,2 (2001): 207-36.
  3. Chaudhry, A et al. “Detection of the Stellate and Thoracic Sympathetic Chain Ganglia with High-Resolution 3D-CISS MR Imaging.” AJNR. American journal of neuroradiology vol. 39,8 (2018): 1550-1554. doi:10.3174/ajnr.A5698
  4. Kwon, Oh Jin et al. “Morphological Spectra of Adult Human Stellate Ganglia: Implications for Thoracic Sympathetic Denervation.” Anatomical record (Hoboken, N.J. : 2007) vol. 301,7 (2018): 1244-1250. doi:10.1002/ar.23797
  5. Yin, Zhaoyang et al. “Neuroanatomy and clinical analysis of the cervical sympathetic trunk and longus colli.” Journal of biomedical research vol. 29,6 (2015): 501-7. doi:10.7555/JBR.29.20150047
  6. Carter, Jason R, and David S Goldstein. “Sympathoneural and adrenomedullary responses to mental stress.” Comprehensive Physiology vol. 5,1 (2015): 119-46. doi:10.1002/cphy.c140030
  7. Yaribeygi, Habib et al. “The impact of stress on body function: A review.” EXCLI journal vol. 16 1057-1072. 21 Jul. 2017, doi:10.17179/excli2017-480
  8. Fontes, Marco Antônio Peliky et al. “Emotional stress and sympathetic activity: contribution of dorsomedial hypothalamus to cardiac arrhythmias.” Brain research vol. 1554 (2014): 49-58. doi:10.1016/j.brainres.2014.01.043
  9. Lipov, Eugene G et al. “A unifying theory linking the prolonged efficacy of the stellate ganglion block for the treatment of chronic regional pain syndrome (CRPS), hot flashes, and posttraumatic stress disorder (PTSD).” Medical hypotheses vol. 72,6 (2009): 657-61. doi:10.1016/j.mehy.2009.01.009
  10. Park, Jeanie et al. “Baroreflex dysfunction and augmented sympathetic nerve responses during mental stress in veterans with post-traumatic stress disorder.” The Journal of physiology vol. 595,14 (2017): 4893-4908. doi:10.1113/JP274269
  11. Wenner, Megan M. “Sympathetic activation in chronic anxiety: not just at the “height” of stress. Editorial Focus on “Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety”.” Journal of neurophysiology vol. 120,1 (2018): 7-8. doi:10.1152/jn.00220.2018
  12. Fonkoue, Ida T et al. “Symptom severity impacts sympathetic dysregulation and inflammation in post-traumatic stress disorder (PTSD).” Brain, behavior, and immunity vol. 83 (2020): 260-269. doi:10.1016/j.bbi.2019.10.021
  13. Orr, Scott P et al. “Psychophysiology of post-traumatic stress disorder.” The Psychiatric clinics of North America vol. 25,2 (2002): 271-93. doi:10.1016/s0193-953x(01)00007-7
  14. Sherin, Jonathan E, and Charles B Nemeroff. “Post-traumatic stress disorder: the neurobiological impact of psychological trauma.” Dialogues in clinical neuroscience vol. 13,3 (2011): 263-78. doi:10.31887/DCNS.2011.13.2/jsherin
  15. Miao, Xue-Rong et al. “Posttraumatic stress disorder: from diagnosis to prevention.” Military Medical Research vol. 5,1 32. 28 Sep. 2018, doi:10.1186/s40779-018-0179-0
  16. Kulkarni, Kalpana R et al. “Efficacy of stellate ganglion block with an adjuvant ketamine for peripheral vascular disease of the upper limbs.” Indian journal of anaesthesia vol. 54,6 (2010): 546-51. doi:10.4103/0019-5049.72645
  17. Rajesh, M C et al. “Stellate Ganglion Block as Rescue Therapy in Refractory Ventricular Tachycardia.” Anesthesia, essays and researches vol. 11,1 (2017): 266-267. doi:10.4103/0259-1162.194566
  18. Lipov, Eugene G et al. “Stellate ganglion block improves refractory post-traumatic stress disorder and associated memory dysfunction: a case report and systematic literature review.” Military medicine vol. 178,2 (2013): e260-4. doi:10.7205/MILMED-D-12-00290
  19. Lynch, James H. “Stellate ganglion block treats posttraumatic stress: An example of precision mental health.” Brain and behavior vol. 10,11 (2020): e01807. doi:10.1002/brb3.1807
  20. Summers, Mary R, and Remington L Nevin. “Stellate Ganglion Block in the Treatment of Post-traumatic Stress Disorder: A Review of Historical and Recent Literature.” Pain practice : the official journal of World Institute of Pain vol. 17,4 (2017): 546-553. doi:10.1111/papr.12503
  21. Mulvaney, Sean W et al. “Stellate ganglion block used to treat symptoms associated with combat-related post-traumatic stress disorder: a case series of 166 patients.” Military medicine vol. 179,10 (2014): 1133-40. doi:10.7205/MILMED-D-14-00151
  22. Lynch, James H et al. “Behavioral health clinicians endorse stellate ganglion block as a valuable intervention in the treatment of trauma-related disorders.” Journal of investigative medicine : the official publication of the American Federation for Clinical Research vol. 69,5 (2021): 989-993. doi:10.1136/jim-2020-001693
  23. Lynch, James H et al. “Effect of Stellate Ganglion Block on Specific Symptom Clusters for Treatment of Post-Traumatic Stress Disorder.” Military medicine vol. 181,9 (2016): 1135-41. doi:10.7205/MILMED-D-15-00518
  24. Tian, Ying et al. “Effective Use of Percutaneous Stellate Ganglion Blockade in Patients With Electrical Storm.” Circulation. Arrhythmia and electrophysiology vol. 12,9 (2019): e007118. doi:10.1161/CIRCEP.118.007118
  25. Datta, Rashmi et al. “A study of the efficacy of stellate ganglion blocks in complex regional pain syndromes of the upper body.” Journal of anaesthesiology, clinical pharmacology vol. 33,4 (2017): 534-540. doi:10.4103/joacp.JOACP_326_16
  26. Cha, Yong-Mei et al. “Stellate ganglion block and cardiac sympathetic denervation in patients with inappropriate sinus tachycardia.” Journal of cardiovascular electrophysiology vol. 30,12 (2019): 2920-2928. doi:10.1111/jce.14233
  27. Sahoo, Rajendra K et al. “Stellate ganglion block as rescue therapy in drug-resistant electrical storm.” Annals of cardiac anaesthesia vol. 24,3 (2021): 415-418. doi:10.4103/aca.ACA_168_19
  28. Albazaz, Raneem et al. “Complex regional pain syndrome: a review.” Annals of vascular surgery vol. 22,2 (2008): 297-306. doi:10.1016/j.avsg.2007.10.006
  29. Yucel, Istemi et al. “Complex regional pain syndrome type I: efficacy of stellate ganglion blockade.” Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology vol. 10,4 (2009): 179-83. doi:10.1007/s10195-009-0071-5
  30. Singh Rana, Shiv Pratap et al. “Stellate ganglion pulsed radiofrequency ablation for stretch induced complex regional pain syndrome type II.” Saudi journal of anaesthesia vol. 9,4 (2015): 470-3. doi:10.4103/1658-354X.159480
  31. Datta, Rashmi et al. “A study of the efficacy of stellate ganglion blocks in complex regional pain syndromes of the upper body.” Journal of anaesthesiology, clinical pharmacology vol. 33,4 (2017): 534-540. doi:10.4103/joacp.JOACP_326_16
  32. Makharita, Mohamed Y et al. “Effect of early stellate ganglion blockade for facial pain from acute herpes zoster and incidence of postherpetic neuralgia.” Pain physician vol. 15,6 (2012): 467-74.
  33. “How SGB Works.” Stella Center,