- Treatment
Ketamine therapy for
treatment-resistant
depression & PTSD
Ketamine therapy for treatment-resistant
depression & PTSD
Medically supervised IV ketamine infusions that can reduce symptoms of depression, PTSD, and anxiety — often within hours, not weeks. Personalized care from board-certified clinicians in New York.
Why patients choose Ketamine Therapy
70%
Response rate in treatment-resistant depression
24h
Onset of relief for many patients
4–6
Infusions in a standard initial course
30+
Years of safety data in clinical use
Results vary by individual. All treatments are preceded by a thorough clinical evaluation.
- Board-certified psychiatrists
- Evidence-based protocols
- Personalized treatment plans
- 281 Broadway, New York City
- Insurance support available
- — What it is
What is ketamine therapy?
Ketamine therapy uses sub-anesthetic doses of ketamine — administered intravenously under direct clinical supervision — to rapidly reduce symptoms of treatment-resistant depression, PTSD, anxiety, and suicidal ideation.
Unlike traditional antidepressants that target serotonin and can take 4–6 weeks to work, ketamine acts on the brain's glutamate system and can produce meaningful relief within 24–72 hours of the first infusion.
It is one of the most significant breakthroughs in psychiatry in decades — offering hope to the roughly 30% of people with depression who don't respond to conventional treatment.
What ketamine therapy is not
Ketamine therapy is not a standalone cure and works best as part of a comprehensive mental health plan that may include therapy, lifestyle support, and ongoing monitoring by your Hudson Mind clinician.
How ketamine works in the brain
1
Blocks NMDA receptors
ketamine binds to N-methyl-D-aspartate receptors, reducing glutamate-driven hyperactivity linked to depression and trauma.
2
Triggers BDNF release
stimulates brain-derived neurotrophic factor, promoting new synaptic growth and neural plasticity.
3
Restores neural connectivity
depression literally shrinks synaptic connections. Ketamine helps rebuild these pathways quickly.
4
Creates a window for change
enhanced neuroplasticity post-infusion makes this an ideal time to reinforce gains through therapy.
- How ketamine works in the brain
1
Blocks NMDA receptors
ketamine binds to N-methyl-D-aspartate receptors, reducing glutamate-driven hyperactivity linked to depression and trauma.
2
Triggers BDNF release
stimulates brain-derived neurotrophic factor, promoting new synaptic growth and neural plasticity.
3
Restores neural connectivity
depression literally shrinks synaptic connections. Ketamine helps rebuild these pathways quickly.
4
Creates a window for change
enhanced neuroplasticity post-infusion makes this an ideal time to reinforce gains through therapy.
- — Who it helps
Conditions we treat with ketamine therapy
Ketamine therapy is most effective for people who have tried conventional treatments without adequate relief.
01
Treatment-resistant depression
Failed two or more adequate antidepressant trials. Ketamine offers rapid relief where SSRIs and SNRIs have not.
02
PTSD & trauma
Complex and chronic PTSD including military trauma, childhood adversity, and assault. Often combined with SGB.
03
Anxiety disorders
Generalized anxiety, social anxiety, and panic disorder that has not responded to standard pharmacotherapy.
04
Suicidal ideation
Ketamine has demonstrated rapid anti-suicidal effects and may be appropriate in acute or crisis situations.
05
OCD
Emerging evidence supports ketamine for treatment-resistant obsessive-compulsive disorder.
06
Bipolar depression
Depressive episodes in bipolar disorder, under careful monitoring by a Hudson Mind psychiatrist.
- — Signs you may benefit
Symptoms ketamine therapy may address
If you're experiencing several of the following, you may be a candidate for ketamine therapy at Hudson Mind.
- Persistent low mood or inability to feel pleasure (anhedonia)
- Recurring thoughts of suicide or self-harm
- Severe anxiety that disrupts daily life
- Hypervigilance, flashbacks, or emotional numbing from trauma
- Chronic fatigue, brain fog, and poor concentration
- Tried 2+ antidepressants without adequate improvement
- Sleep disturbances linked to mood or trauma
- Social withdrawal and loss of motivation
- Emotional flatness on current medications
- — Our protocol
How Hudson Mind treats with ketamine
Our ketamine protocol is grounded in clinical evidence and refined by real-world patient outcomes. Every step is supervised by a board-certified psychiatrist.
01
Free discovery call
A complimentary call with our intake team to walk through the onboarding process, insurance and fees, and a treatment overview—plus any questions you have. It's optional, but most patients find it helpful to get logistical questions answered before meeting with a provider.
- Initial step
02
Comprehensive psychiatric evaluation
Before any treatment begins, you meet with a Hudson Mind provider for a 45-60 minute evaluation covering your history, diagnoses, prior trials, and goals. This informs your personalized treatment plan.
- Meet a provider
03
IV ketamine infusions (4–6 sessions)
Infusions are administered intravenously over 40–60 minutes in our clinical setting. You remain awake and reclining throughout. Vitals are continuously monitored. The experience is calm and mildly dissociative for most patients.
- Core treatment
04
Integration support
The neuroplasticity window following ketamine infusions is a powerful time for therapeutic work. Hudson Mind coordinates with your existing therapist or can refer you to integration-focused therapists who specialize in working alongside ketamine protocols.
- Recommended
05
Ongoing monitoring & maintenance
After your initial course, we evaluate your response and design a maintenance plan. Some patients sustain results for months; others benefit from a booster infusion every 4–8 weeks. We track your progress and adjust your plan accordingly.
- Ongoing
06
Spravato® (esketamine) as an alternative
If you prefer an FDA-approved, insurance-covered option, Hudson Mind also offers Spravato® (esketamine nasal spray) for qualifying diagnoses. Our team will help determine which approach is the better fit.
- FDA approved
- — The Experience
What to expect at your infusion
Here's what a typical ketamine therapy experience looks like at Hudson Mind, from preparation to post-infusion care.
1
Before your infusion
Fast for 4–6 hours before your appointment. Wear comfortable clothing. You'll need a friend or rideshare to take you home — driving after infusions is not permitted. Our team will send you a preparation guide in advance.
2
Arrival & setup
You'll be settled into a comfortable, quiet room. A nurse or clinician places a small IV line and connects monitoring equipment to track your heart rate and blood pressure throughout.
3
The infusion
The infusion runs over 40–60 minutes. You may notice a mild floating or dreamy sensation, altered perception of time, or mild visual effects. These are normal and resolve quickly after the infusion ends. Many patients find the experience peaceful.
4
Recovery & discharge
After the infusion ends, you'll rest in our recovery area for 15–30 minutes while the effects fully clear. Most patients feel grounded and well within an hour. You'll debrief briefly with a clinician before leaving.
5
In the days that follow
Many patients notice mood improvement within 24–72 hours. Some experience it the same day. Your care team will check in following each infusion and after your full course to assess your response and next steps.
Not sure if treatment is right for you?
Our team will walk you through your options and help you take the next step — no pressure, no commitment required.
Treatments offered
5
TMS FDA approved
2008
Ketamine in clinical use
50+ yrs
"Ketamine represents a genuine paradigm shift in how we treat depression. For patients who have tried everything and lost hope, seeing a response within a day or two can be profoundly life-changing. "
Hudson Mind Team
- — Questions
Frequently asked questions
Still have questions? Book a free 15-minute phone consultation with our care team.
Ready to find out if ketamine is right for you?
Our team will walk you through your options, answer your questions, and help you take the next step — with no pressure.
What is ketamine therapy?
How quickly does ketamine therapy work?
How many ketamine infusions are typically needed?
Is ketamine therapy safe?
Does insurance cover ketamine infusions?
What does a ketamine infusion feel like?
Can ketamine therapy be combined with antidepressants?
- — Related Care
Other treatments at Hudson Mind
Ketamine therapy is often part of a broader treatment plan. Explore complementary interventions we offer.
Treatment
Spravato® (Esketamine)
FDA-approved nasal spray esketamine. Insurance-covered for qualifying diagnoses. Offered alongside IV ketamine at Hudson Mind.
Treatment
TMS Therapy
FDA-approved, non-invasive magnetic brain stimulation. No medication, no sedation. Covered by most major insurance plans.
Treatment
SGB (Stellate Ganglion Block)
A nerve block targeting the sympathetic nervous system. Used for PTSD, anxiety, and trauma-related symptoms.
Take the first step toward feeling better
Book a consultation with a Hudson Mind clinician to discuss whether Ketamine Therapy is the right next step for you.
